official website and that any information you provide is encrypted I tell patients to take a lukewarm or cool shower, [to use] heavy lubricants, body oil, those kinds of thingsbecause the dryness is really severe. . This means that three-quarters of these patients are looking at a new lease on life, said Dr. Chari, of the Tisch Cancer Institute at Mount Sinai in New York. Apalutamide Elicits PSA Response, Lowers Progression to Castration Resistant Disease in mCSPC, Nurse Investigators on Using Weighted Blankets to Alleviate Anxiety During Cancer Treatment Infusions, Best Practices on Managing AEs With Darolutamide Plus ADT/Docetaxel in mHPSC, Jessica MacIntyre on Improving LLS Referrals For Patients With Hematologic Malignancies. CRS and cytopenia were primarily observed in early cycles and were reversable. It also binds CD3, a protein on the surface of immune T-cells. Unable to load your collection due to an error, Unable to load your delegates due to an error. Teclistamab, a B-cell maturation antigenCD3 bispecific antibody, in patients with relapsed or refractory multiple myeloma (MajesTEC-1): a multicentre, open-label, single-arm, phase 1 study. Scientists use genetic rewiring to increase lifespan of cells. It is used in adults who require systemic treatment (treatment with medicines affecting the whole body). Through patient education tactics, oncology nurses can help patients with multiple myeloma mitigate the oral and dermatologic toxicities associated with talquetamab. Talquetamab (JNJ-64407564) is an investigational bispecific antibody. In patients with multiple myeloma, GPRC5D is overexpressed and . All rights reserved. In total 70% of patients experienced Cytokine Release Syndrome (CRS) but all events were minor. Side effects, CRS, but also I wanted to point out, unique to this target, we also saw nail toxicity, because GRC5D is expressed on keratinized tissue, also dysgeusia, which, which is a little . sneezing. 2023 Mar 17;15(6):1819. doi: 10.3390/cancers15061819. J Oncol Pharm Pract. Following our recent Biologics License Application submission to the US FDA, we look forward to working with the agency to make this available as a treatment option in the short term and continuing our longer-term investigations of talquetamab as we aim to develop additional options for patients with this complex blood cancer," said Sen Zhuang, vice president of clinical R&D at Janssen Research & Development. The median time to a measurable response was approximately 1.2 months in both dosing groups, and the median duration of response is 9.3 months to date with weekly dosing. HealthTree Foundation / Myeloma Crowd is a qualified 501(c)(3) tax-exempt organization. Initial treatment for multiple myeloma may involve chemotherapy, immunotherapy, and corticosteroid treatment. Talquetamab is one of several new drugs in the hopper that are giving us triple+ refractory myelomapatients a heart full of hope. These are patients whove had typically five lines of therapy over several years. Step-up dose 1 . More than 30% of patients in both groups had a complete response or better, and nearly 60% had a very good partial response or better. Heres the joy part. I am looking forward to seeing how the reduction in frequency of administration will improve the side effects I've been experiencing. But of course nothing works forever. Learn more, Enzalutamide improves survival rates for men with metastasized prostate cancer when added to standard treatment, the results from the clinical trial. Also, I discourage patients from putting fans next to their bed, because a lot of patients would say they really noticed it was worse at night.. The most common side effects reported in the clinical trial for Tecvayli were hypogammaglobulinaemia (a condition in which the level of immunoglobulins (antibodies) in the blood is low and the risk of infection is high), cytokine release syndrome (CRS) (i.e. This is a whole new era of cancer therapy, Dr. Chari said. Careers. Just under three-quarters of participants given a lower or higher dose of talquetamab in the Phase 2 portion of J&J's study responded to treatment, with around a third of each group achieving remission of their cancer. Ongoing trials are assessing the optimal phase 2 dose, as well as assessing the agents efficacy in combination with approved and investigational therapy. For example, skin and ear problems, which can sometimes affect patients a little bit differently, but can also be a quality-of-life issue. Infections also occurred in more than half of patients on each drug dose, with 17% and 12% respectively graded as more severe. . Track your myeloma and find treatment options, Journal your myeloma story in video, audio and writing, Learn from 150+ myeloma experts in video lessons, Find a free personal coach to help navigate your myeloma, Join our new social media app for myeloma patients, Tackle challenges and crush your fitness goals together, Stay up-to-date with thousands of myeloma news articles, Listen to one-on-one interviews with experts on clinical trials, Attend in-person meetings with myeloma experts, Join community groups with other patients and caregivers, Answer survey questions to advance myeloma research, Find answers to commonly asked questions when navigating HealthTree services. Online ahead of print. or who could not receive these therapies without unacceptable side effects. Kerry Boyle D.Ac., M.S., L.Ac., Dipl. Read on for details and takeaways from the meeting over the weekend: Like many new drug targets, its name is complicated and better off abbreviated. Although all oral symptoms were categorized as grade 1 or 2, they still had a significant effect on quality of life and treatment continuation; dysgeusia was responsible for 3 cases of dose interruptions, 1 case of dose reduction, and 1 treatment discontinuation; dysphagia was the catalyst for 3 cases of treatment interruptions. At the time of data cut-off, 76 patients had been enrolled in the trial at Mount Sinai Hospital. Talquetamab, a G protein-coupled receptor family C group 5 member D X CD3 bispecific antibody, in relapsed/refractory multiple myeloma: updated efficacy and safety results from MonumenTAL-1. Rich has written for a number of online and print publications over the last decade while also acting as film critic for several radio broadcasters and podcasts. Nurse Practitioners/Physician's Assistants, 2022 ASCO Genitourinary Cancers Symposium Urothelial Cancer Updates, Contemporary Concepts in Hematologic Oncology, Insights from Experts at Mayo Clinic on Translating Evidence to Clinical Practice, Optimizing Outcomes in Patients with HER2+ Metastatic Breast Cancer, | 2022 ASCO Genitourinary Cancers Symposium Urothelial Cancer Updates, | Contemporary Concepts in Hematologic Oncology, | Insights from Experts at Mayo Clinic on Translating Evidence to Clinical Practice, | Optimizing Outcomes in Patients with HER2+ Metastatic Breast Cancer. Both of those therapies bind to BCMA, a protein targeted by a wave of new drugs from Roche, Regeneron, AbbVie and Pfizer. (December 10, 2021) Mount Sinai scientists have become the first to report a potentially serious side effect related to a new form of immunotherapy known as CAR-T cell therapy, which was recently approved for the treatment of multiple myeloma. We've been so busy adding drugs to the arsenal that [were] catching up to figure out the right sequences and unanswered questions.. In total, 165 patients were enrolled in the trial. Patients with measurable MM who were relapsed/refractory or . Teclistamab (JNJ-64007957) may be a safe and efficacious treatment option for patients with relapsed/refractory multiple myeloma, according to findings from a phase I study presented at the 2020 American Society of Clinical Oncology . and transmitted securely. So that would indicate the possibility that GPRC5D could potentially kill myeloma cells left behind after BCMA-based regimens are used! Talquetamab had moderate side effects. This novel blood clot treatment doesn't increase bleeding risk, Why young women have more adverse outcomes after a heart attack than young men, Gut microbiome appears to fluctuate throughout the day and across seasons, One-hour endoscopic procedure could eliminate the need for insulin for type 2 diabetes, New clues to slow aging? Healthy plasma cells produce antibodies to help people fight disease. The Phase 2 trial data has yet to be formally published in a peer-reviewed journal, however, the Phase 1 data has just been published in The New England Journal of Medicine. This is a list of most of the side effects I've had since I started talquetamab. Talquetamab appears to have a have favorable risk/benefit profile in RRMM with durable responses and manageable toxicities. Nearly all multiple myeloma patients will relapse at some point in their treatment, becoming resistant to first one, then another frontline intervention. Side effects were relatively frequent, but typically mild. This allowed the treatment priority and accelerated pathways through approval processes. Data showed skin- and taste-related side effects were common, but typically rated mild. An official website of the United States government. In total, 55.3% of patients experienced dysgeusia, 21.1% experienced dry mouth, and 22.4% experienced dysphagia. Talquetamab is an investigational, off-the-shelf (ready to use), bispecific T-cell engager antibody targeting both GPRC5D, a novel drug target . The new exclusion criteria could represent an incremental headwind for Bluebird should it get to market, wrote SVB Securities analyst Mani Foroohar. A Phase 3 Randomized Study Comparing Talquetamab SC in Combination With Daratumumab SC and Pomalidomide (Tal-DP) or Talquetamab SC in Combination With Daratumumab SC (Tal-D) Versus Daratumumab SC, Pomalidomide and Dexamethasone (DPd), in Participants With Relapsed or Refractory Multiple Myeloma who Have Received at Least 1 Prior Line of Therapy (Abstract #S188) and talquetamab (Abstract #S183) cohorts of the TRIMM-2 study will be featured as oral presentations at the European Hematology Association (EHA) 2022 Congress taking place in Vienna, . "Human natural killer cell" [Micrograph]. A new therapy that makes the immune system kill bone marrow cancer cells was successful in as many as 73 percent of patients in two clinical trials, according to researchers from The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. Management of Relapsed-Refractory Multiple Myeloma in the Era of Advanced Therapies: Evidence-Based Recommendations for Routine Clinical Practice. Ajai Chari, MD, discusses the safety and efficacy of talquetamab plus daratumumab in heavily pretreated patients with multiple myeloma, initial data from phase 1b TRIMM-2 trial, and the potential . "With a median follow-up of 14.9 months (range 0.5+ to 29.0), 74.1 percent of patients treated at the SC [subcutaneous] 0.4 mg/kg dose administered weekly achieved a response, 59.4 percent achieved a very good partial response or better, 33.6 percent achieved a complete response or better and 23.8 percent achieved a stringent complete response," reported pharmaceutical company Johnson & Johnson in a press release. No unexpected side effects were seen with this association. 2022 Aug 11;387(6):495-505. doi: 10.1056/NEJMoa2203478. News release. The gist was that the temporary side effect was nothing if the drug works! The primary objectives were to identify the recommended phase 2 doses (RP2Ds) (part 1) and assess talquetamab's safety and tolerability at the RP2Ds (part 2). In July 2012, Genmab entered into a collaboration with Janssen Biotech, Inc. (Janssen) to create and develop bispecific antibodies using Genmab's DuoBody technology platform. Many of those with a very good partial response had a 90% improvement., He told MNT that phase 3 trials are now underway using a the 2-weekly dosing pattern. (Its also found on hairfollicle cells but dont worry youre not going to lose your hair again.) Ive recently retired from a career as a CPA. Anemia, in this context, can be worrisome as a potential sign of emerging blood cancer. [Bispecific antibodies in multiple myeloma]. The researchers said very few patients (5-6%) stopped talquetamab treatment because of side effects. Keep up with the story. One of the things that I think is very telling with efgartigimod is, no matter what subgroup we looked at, it showed a benefit over placebo, said Broome. Oyster mushrooms contain antioxidants, which may lower cancer risk. Attendees of the American Society of Hematology's annual meeting walk across a conference hall in December 2022. Also at ASH, Roche and Bristol Myers Squibb presented data for a GPRC5D-targeting bispecific antibody and cell therapy, respectively. The same side effects that I mentioned are cytokine release syndrome. All participants had received at least three prior treatments, including other types of drugs. Type. Moreover, with proper education regarding treatment-emergent adverse event (TEAE) management, nurses can play a critical role in improving quality of life for patients receiving talquetamab.1, Nursing education, support, and management is absolutely vital, Aronson said in a presentation on the agents AE profile during the International Myeloma Societys 6th Annual Nursing Symposium. Editors note: This story has been updated to clarify the status of Vertex and CRISPRs regulatory application. Thanks for the information in this one in particular. They simultaneously plant a target flag on cancer cells and give immune cells a roadmap to that target. Injection-site reactions were observed in 7.9% of patients. The immunotherapy being trialled is called talquetamab. Bookshelf Were hoping that this will soon become available so that patients can benefit.. Hydrate, hydrate, hydrate, she said. Dose delays may also be an effective method of mitigating oral and dermatologic therapies, she . The response rate observed in this cohort, which Dr. Chari explained is higher than that of most currently accessible therapies, suggests talquetamab could offer a viable option for patients with hard-to-treat myeloma, offering a chance to extend patient . Myeloma stories, Myeloma clinical trials, Myeloma 101 articles and events with Myeloma The adult patient, for instance, currently needs transfusions to handle her anemia and has intermittent bouts of chronic pain. Drugs targeting GPRC5D, for instance, could offer an alternative to BCMA-binding treatments. 5 months after I stopped, I recovered my sense of taste. 2023 Apr 28. doi: 10.1007/s00277-023-05218-1. Cure Hub Side Effect Solutions My Journal University Coach Connect . This means slippery stuff [that] goes down, she explained. Talquetamab fo Multiple Myeloma. The blood tests which measured my myeloma (M spike, IGG, free light chains) all stayed pretty stable. And at the various doses, deep, ongoing responses were noted. Were looking at all of that, to try to figure out how to optimize the combination of these drugs in a highly effective regimen, said Tendler. The myeloma cancer cells also build up in the bone marrow and form tumors. Investigators used a step-up dosing schema and premedications to mitigate AEs. Here are three storylines to emerge so far.
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