Clinical Guide to Laboratory tests. The research work was carried out in collaboration between all authors. We currently have no information for JUSTICIA PECTORALIS overview. Packed cell volume (PCV) and mean corpuscular volume (MCV) in treated rats with JCEE were statistically unperturbed compared to the control. Ewe eje improves the production of white blood cells and other antibodies, all which are essential for strengthening immunity. Occupational Health and Safety in the Care and Use of Research Animals. The plant is transplanted in the spring. The botanical name- Justicia carnea was coined after a scotish- James Justice, who happens to have found the plant first. Prof. F.O. The protein content may help in cellular functions and are building blocks for structural and functional biomolecules. what are the pros and cons of testosterone replacement therapy? Correspondence to Cassani, J., Dorantes-Barrn, A. M., Novales, L. M., Real, G. A., & Estrada-Reyes, R. (2014). However, there have not been scientific backing on this claim, yet, from the antiviral properties of other species of justicia, it could be that this plant possess antiviral properties which is utilized in the treatment of hepatitis infection. No observable focal sclerosis of renal glomeruli, capsular spaces around the glomerulus appears normal with distinct layering of renal microcellular structures. The mixture was allowed to cool and centrifuged at 650g for 10min to obtain the supernatant. J Am Diet Assoc. 2. Parameter that were determined include total haemoglobin concentration (HGB), packed cell volume (PCV), red blood cell count (RBC), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), mean corpuscular volume (MCV), white blood cell count (WBC), Lymphocyte count (LYM), MID sized cell (MID), Granulocyte Count (GRM) and platelet count (PLT). 50mg/kg-1200mg/kg treatment relative to control treatment showed varied degree of renal injury that is dose dependent. Vitamin C and E are antioxidants. Justicia carnea needs bright, indirect light to thrive. Each of the rats received 1500, 2900 and 5000mg/kg body weight of JCEE respectively and examined within 24h for manifestation of toxicity. Consumption of medicinal plants has diverse therapeutic benefits and could also have toxic effect. Effects of kolaviron on hepatic oxidative stress in streptozotocin induced diabetes. Acta Sci Pol Technol Aliment. The absorbance was taken at interval of 1min for 3min at 480nm. Compared to the control, total protein in liver and kidney were statistically not altered except rats that were administered with 1200mg/kg JCEE that showed significant (p<0.05) decrease in the liver. Materials and Methods Plant material Justicia carnea leaves used in this study were collected from Ozalla Isuofia in Anambra State and identified by Mr. Ozioko 16. Rats were further observed for extended hours of 48h to see if mortality would occur. It may also affect the activity of hormones. Tags: benefits of justicia carnea, health benefit of justicia carnea, justicia carnea . Cardioprotective role of Justicia traquebareinsis Linn. The animals were allowed free access to rat chow and water ad libitum. -Amylase binding-interaction with JCAE was also investigated using fluorescence spectroscopy and molecular docking. Molecules (Basel, Switzerland), 19(12), 2144221461. It can be used to manage diabetes consition properly. The effect of the ethanol extract of Justicea carnea (JC) leaves in phenylhydrazine induced-anemia albino rats on haematological and lipid profile parameters was investigated. 2010;4(8):6804 https://doi.org/10.5897/JMPR09.487. How Justicia Betonica is effective for various diseases is listed in repertory format. It also grows in some Caribbean islands, including Trinidad and Tobago . A., Bezerra, G. A., Matos, F. J., and Viana, G. S. Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. The flowers are slightly fragrant and mostly sterile. It also can be used in combination with other vegetables such as the Efinrin (scent leaves), ugwu etc. The spectacular rosy plumes of the flamingo-colored flower are distinctive and attract hummingbirds to pollinator gardens. These antibodies help prevent infections and fight off diseases. Over time, they cause atherosclerosis and myocardia infarction. This is due to the inability of the pancreatic beta cells to secrete insulin, which transports glucose to cells, or the inability of cells of the body to recognize insulin. Group 2, 3, 4, 5, 6 were respectively administered orally with 50, 100, 500, 800 and 1200mg/kg body weight of JCEE once daily for 14days using an oral gavage. Braz. long (20 cm), densely packed with pink to crimson tubular flowers. 2015;6(7):265270. Studies have shown that ewe eje isnt capable of causing damage to the liver. Check these Great Plant Combination Ideas with Justicia, Eye-Catching Retaining Walls and Staircases, An Eye-Catching Mediterranean Garden with Agave, Aloe and Pincushion, A Striking Water-Wise Border with Agave, Cactus and Ocotillo, A Beautiful Duo with Agave 'Blue Flame' and 'Blue Glow', A Long-Lasting Summer Garden Idea with Marigold and Sage, 8, 9, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, H1, H2. statement and Due to the local availability, easy access and relatively low cost, medicinal plants are gaining attentions in health care programmes. DOI: https://doi.org/10.1089/ars.2007.1901. During the growing season, the justicia (plant) should be watered thoroughly with room temperature water. Tissues were processed automatically using automatic tissue processor (Leica TP 1020) and allowed to pass through varying percentage of alcohol and absolute alcohol for the purpose of dehydration following dewaxing in Xylene for 15mins. Keep an eye out for glasshouse red spider mite and glasshouse whitefly. This amazing, Coriander seeds as well as the leaves are widely used as spices in flavoring foods and drinks, and, Cashew leaves: health benefits and side effects of Anacardium occidentale, Fig leaves tea: Amazing benefits and best recipes, Negro pepper: 12 health benefits of uda seed and side effects. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Recently, it has also been reported that the species possess cardioprotective properties, antioxidant and are generally rich in vitamins and minerals [10,11,12]. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Google Scholar. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. Article Afr J Tradit Complement Altern Med. Phytother Res 2011;25(3):444-450. It is not. The results of effect of methanol leaf extract of Justicia carnea on albumin and total protein concentrations in CCl 4-intoxicated rats shown as in Table 2 showed that there was a significant (p<0.05) decrease in serum albumin and total protein concentrations . Once the roots have established, adjust watering to three to five days apart. https://doi.org/10.1016/j.jada.2008.06.430. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Kone WM, Koffi AG, Bomisso EL, Tra Bi FH. The plant looks great along garden borders and near building foundations. It does not tolerate low temperatures at all. Wash the Justicia carnea leaves thoroughly to eliminate all forms of insects and dust. degree in Biochemistry fromUniversity of Ado-Ekiti, Ekiti State, Nigeria and University of Ibadan, Nigeriarespectively. With exception of low doses that showed normal morphology of the hepatocyte and sinusoid that is not infiltrated, high doses of extract greater than 500mg/kg showed mild fat congestion in the central venules with liver parenchyma showing area of hemorrhage compared to the control. Read also (Cashew leaves: health benefits and side effects of Anacardium occidentale). The animals were randomly distributed into cages and allowed to acclimatize for 2 weeks in a well ventilated room under natural lighting condition. Control treated group showed normal micromorphological sections. 2016;5(1):6270 https://doi.org/10.1016/j.joad.2015.08.006. Article Justicia Carnea leaves extract contains a rich supply of iron, riboflavin, vitamins A, C, E, B1, B2, B9, and B12. Influence of ethanolic extracts of dried fruit of Xylopia aethiopica (Dunal) A. Akintimehin, E.S., Karigidi, K.O., Omogunwa, T.S. J Ethnopharmacol 1985;13(1):3-49. The major use of Justicia carnea leaves is to improve blood production. Liver superoxide dismutase (SOD) activity was significantly (p<0.05) increased at 1200mg/kg while other tested doses caused no detrimental effect on glutathione, catalase, SOD and malondialdehyde level in liver and kidney. This is why you should avoid potting them if you live in colder areas. Keep the soil moist, but not waterlogged. Grows up to 4-6 ft. tall (120-180 cm) and 2-3 ft. wide (60-90 cm). and M.Sc. Summer temperatures above 77 degrees Fahrenheit (25 C) are perfect. Ashwagandha tea: 10 benefits, side effects and recipes, 7 interesting health facts about Black sapote fruits. Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats. The haematological indices of the blood samples were determined using an automated URIT 2900 Plus 3 Differential Haematological Analyzer. et al. Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents. https://doi.org/10.1016/j.jep.2005.06.013. Tietz NW. Philadelphia: WB. Justicia carnea [jus-TEE-see-ah, KAR-nee-uh] is popularly known as the Brazilian Plume Flower. Yes my readers. J Nat Prod 1988;51(4):804-805. These minerals help in boosting blood production, which is why the plant is called ogwu obara (blood medicine) among the Igbo people of Southern Nigeria. In which ever condition, the blood glucose level increases abnormally. Rather it can assist with improveing liver function such as detoxification. Treatments of all experimental animals were performed following Principle of Laboratory Animal Care manual guidebook of National Institute of Health as approved by the Research Ethics Committee of Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State. They also maintain our skin tone and texture, and help in reproductive functions. The liver and kidney of rats administered with 500mg/kg JCEE and above demonstrated slight increase in MDA level with significant (P<0.05) increase only observed in the liver of rats that received 1200mg/kg of extract. Histopathological examination of liver and kidney showed mild to severe pathological lesion in a dose dependent manner. The appropriate dose of Justicia pectoralis depends on several factors such as the user's age, health, and several other conditions. While histology of organs showed no adverse pathological lesions in the internal organs of rats, higher dose (1200mg/kg) over a period of time could cause noticeable liver and kidney injury. Mapanga RF, Musabayane CT. How often should it be watered? Onyeabo, Chimaraoke & Achi, Ngozi & Chima, Ekeleme-Egedigwe & Ebere, Chidinma & Okoro, Chidinma. The resultant liquid after boiling is usually crimson red. Decoction of ewe eje or its leaf extract can lower serum cholesterol and get rid of bad cholesterol (LDL). At this time there is not enough scientific information to determine an appropriate range of doses for Justicia pectoralis. Side effects of Ewe eje (Justicia carnea leaf Side Effects). From this study, the significant increase in platelet counts suggested that the extract could be useful in preventing excessive blood loss (through blood clotting) and resistance of capillary membranes to leakage of red cells when blood vessels are damaged. 1983;53:27589. In a study conducted by Onyeabor and colleagues, the leaf extract of jusiticia carnea reverses the anemic effect of phenylhydrazine on the pack cell volume, red blood cell, and hemoglobin concentrations. 3rd ed. The plant, which is usually green in color and produces pink flowers, belongs to the family of Acanthaceae. The leaves of Justicia carnea contains powerful antioxidant activities and phytochemical components that help reduce oxidative stress, and reduce the risk of development of cancer. 32 years old (Greco et al., 1974), long-term treatment side effects are becoming more critical. Summarily, experimental group shows some degenerative changes that can be termed as necrosis, some mild fibrosis and hemorrhage characterized by the presences of infiltrated red hemorrhagic and inflammatory cells. Arch Toxicol. WebMD does not provide medical advice, diagnosis or treatment. Sci. Chidubem Olovo is a biochemist and a researcher whose interest is centered on the chemistry of natural products, their pharmacological properties and how using the plant sources can improve human healthy living. The spread is equally glorious and can take up 12 15 inches of space. Duan WL, Liang XM. Google Scholar. This is attributed to the anti-hyperlipidaemic properties of the plant. Generic and epigenetic contributions to human nutrition and health: managing genome-diet interactions. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Watering depends on humidity and temperature. It may be, judging from the antidepressant activity of other plant of justicia species whose activity have been studied, proper to state that justicia carnea may possess antidepressant properties. ESA conceived and designed the study. Haematological and biochemical studies on Justicia carnea leave extract in phenylhydrazine induced-anemia in albino rats. Therefore,it is imperative to investigate the effects of the plant on the essential biochemical indices in diabetic rats so as to establish its safety. https://doi.org/10.1016/j.jep.2007.02.011. The perennial plant puts on a never-ending show of radiant flowers from early spring to fall. Catalase activity (U/ml) was measured following the method of Sinha [17]. The red coloration of the decoction made people think that the plant must contain blood boosting compounds. View abstract. The changing faces of glutathione, a cellular protagonist. Justicia carnea does not cause miscarriage or congenital birth defects. J Ethnopharmacol 1984;12(1):93-111. Biochem Pharmacol. Walters DM., Cho Hye-Youn, Kleeberger SR. Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2. The liver and kidneys were excised and rinsed immediately in a normal saline (0.9% Nacl) to remove blood stain, dried between layers of Whatman filter paper, weighed and homogenized to obtain the supernatant for biochemical analysis. 10.9734/ijbcrr/2020/v29i630194. In the study conducted by Onyeabor and his colleagues, it was shown that the leaf extract not only reverses anemic condition, but also lowered the lipid profile of the experimental rats. The aim of this study is to evaluate the effects of J. carnea leaf extract on hematology indices and organ antioxidant system in healthy wistar rats. Venancio, E. T., Rocha, N. F., Rios, E. R., Feitosa, M. L., Linhares, M. I., Melo, F. H., Matias, M. S., Fonseca, F. N., Sousa, F. C., Leal, L. K., and Fonteles, M. M. Anxiolytic-like effects of standardized extract of Justicia pectoralis (SEJP) in mice: Involvement of GABA/benzodiazepine in receptor. The higher LD50 (>5000mg/kg body weight) of J. carnea leaf ethanol extract suggested that the ethanol extract is experimentally safe and not toxic. It helps in replenishing blood lost during period. Aim. Create a membership account to save your garden designs and to view them on any device. When properly boiled in water, the aqueous leaf extract turns red, and when mixed with milk turns pink. Mounanga MB, Mewonob L, Angone SA. The plants cannot be propagated with seeds. Further, 0.5ml of supernatant was treated with 0.5ml of Ellmans reagent (containing 19.8mg of 5,5 dithiobis - (2-nitrobenzoic acid) (DTNB) in 100ml of 0.1% sodium nitrate) and 3.0ml of phosphate buffer (0.2M, pH8.0). https://doi.org/10.13040/IJPSR.0975-8232. The leaves are rich in carbohydrates and proteins, which are for energy production and maintenance of cellular activities. The present study investigated the antioxidant and in vitro antidiabetic capacities of Justicia carnea aqueous leaf extract (JCAE) using -amylase inhibition model. Privacy The compound responsible for this activity is lignan. The renal cortex showed normal glomeruli with mesangial cells and capsular spaces appeared normal (white arrow), the renal tubules appear normal (blue arrow) and interstitial spaces also observed normal (black arrow). J Afr Ass Physiol Sci. However, lowest (50mg/kg) dose of extract significantly elevated MCH and MCHC. van Andel T., Carvalheiro LG. Ewe eje isnt capable of causing any side or negative effects if consumed moderately. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Mr. K.O. Joseph, H., Gleye, J., Moulis, C., Fouraste, I., and Stanislas, E. O-Methoxylated C-glycosylflavones from Justicia pectoralis. Inflammation is a complex biological response of body's tissue to harmful stimuli like infections, toxins and itself. Plantcaretoday.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to amazon.com, how to get rid of leaf eating caterpillar. As reported by science, Justicia carnea is composed of secondary metabolites such as: flavonoids, terpenoids, alkaloids, phenols, saponins and tannins. The shrubby habit of the plant is well-suited for both containers and outside planting. It is believed by local consumers in Ghana to possess anti-anaemic effects that boost blood levels in pregnant women, anaemic patients and also . Although, medically, it is advised you see your doctor or a physician before using the leaf for medicinal uses. As declared by all authors, no competing interests exist. Cookies policy. Total protein concentration in tissue homogenates were determined using biuret method Tietz [16]. In various parts of Africa, several species of Justicia are used in traditional medicine for the treatment of anemia, inflammation, fever, diarrhea, liver diseases and arthritis respiratory and gastrointestinal disorder [8, 9]. CAS The absorbance was read at 412nm against the reagent blank. Materials and Methods 2007;112(1):13844. Mean lethal dose of the extract was found to be above 5000mg/kg body weight (bw). 5. It is obvious that Justicia carnea has potential antianemic, antioxidant, antidiabetic, hepatoprotective, and immune-boosting properties. Lorke D. A new approach to practical acute toxicity testing. J Nat Prod 1988;51(3):599-600. These animals were obtained from the animal house of the Department of Chemical Sciences, Ladoke Akintola University of Technology Ogbomoso Oyo State, Nigeria. The effect of the ethanol extract of Justicea. Eyong EU, Umoh IB, Ebong PE, Eteng MU, Antai AB, Akpa AO. In-vivo studies have revealed that radicals produced from these dietary antioxidants are constantly regenerated back to their active form by GSH in the ascorbate glutathione cycle. Faiza R, Waqas KK, Adeel M, Muhammad G. Detection of bioactive fractions of Justicia adhatoda leaves. 2005;102(2):197201. de Vries, J. X., Tauscher, B., and Wurzel, G. Constituents of Justicia pectoralis Jacq. Antianaemic potentials of some plant extracts on phenyl hydrazineinduced anemia in rabbits. Justicia pectoralis might have many different effects in the body. Leaf extract in isoproterenol induced myocardial infarction in albino rats. Related: The Persian Shield plant is also in the Acanthaceae family. Ethnomedical study and iron content of some medicinal herbs used in traditional medicine in cote divoire for the treatment of anaemia. Relative to the control, liver of rats treated with doses of J. carnea ethanol extract showed varied degree of hepatic injury in a dose dependent manner. Furthermore, increased MID by the extracts could indicate macrophage formation ability and pathogenic scavenging role. It is very rich in iron, a major component is RBC hemoglobin. At the end of the 14th day of administration, the rats were allowed to fast overnight and sacrificed the following morning by anesthetizing each rat in a closed chamber containing drops of chloroform. CAS This study investigated the in-vitro antioxidant activity of ethanol leaf extract of Justicia carnea and its effect on antioxidant status of alloxan-induced diabetic albino rats. In these groups, from mild to severe order; shows observable congested portal vein, the liver parenchyma showed area of harmorrhage, the morphology of the hepatocytes appear pyknotic, some show mild fat infiltration (red arrow) the sinusoids appear fibrotic with infiltration of inflammatory red cells (red arrow). It is also known as Jacobinia carnea, and is a part of the Acanthaceae family along with the Aphelandra squarrosa (Zebra plant) and Crossandra. African J Plant Sci. Blooming from early summer to fall, the flowers are attractive to hummingbirds and butterflies. Ewe eje or ewe ajeri is prepared differently by different folks. This is . The kidney of rats treated with doses of J. carnea ethanol extract revealed dose dependent degree of renal injury (Fig. The weight of organs (liver and kidney) reduced steadily in a concentration dependent manner. 2019;30(4):64554. There are several claims that justicia carnea can prevent epilepsy and convulsion among children. It is nicknamed the Blood leaf, Blood of Jesus, and Jehovah Witness leaf in Nigeria, and is a widely used leaf across states in Nigeria. Make sure to follow the package instructions carefully. In its native habitat, the Justicia carnea plant grows upright and may reach 3 5 feet tall. In some areas, the plant may tolerate temperatures as low as 50 degrees Fahrenheit (10 C). CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Stover PJ, Caudill MA. Emmanuel Sina Akintimehin. Allium satium and Justicia carnea either used alone or co-administered had an ameliorating effect on cadmium toxicity. 1. Add organic matter or compost in the soil and place the plant. The genus Justicia named after the 18th-century Scottish botanist James Justice is a flowering plant in the family Acanthaceae. When it comes to blood boosting and treatment of anemia, justicia carnea has proven beyond doubt to be an effective remedy. 1.3.1 Aetiologyof Anaemia Anaemia may be due to a single factor such as a nutritional deficiency or multifactorial (McEvoy, 2013). BMC Complem Altern Med. The aqueous leaf extract of ewe eje has demonstrated hypoglycaemic and antidiabetic properties; and thus, can be said to assist with blood sugar levels reduction. Relative to control, lymphocyte and granulocyte exhibited no significant difference in all doses while MID was elevated in treated groups with significant increase in rats administered with 500 and 800mg/kg body weight. No. Ewe eje as it is fondly called by the Westerners in Nigeria is a plant known for its blood boosting abilities. 2011;5(9):48992 https://academicjournals.org/journal/AJPS/article-full-text-pdf/6AA410310867. J Ethnopharmacol 2000;70(2):151-159. Generally disease free. While the renal tubules across the tested groups were normal with the interstitial spaces showing moderate congestion and hemorrhage, there appeared some abnormalities in the renal cortex (such as few sclerotic glomeruli with moderately dilated capsular spaces) resulting in fair architectural structure of the kidney (Fig. Consequently, the effects of the extract on MDA level could indicate damage to cell membrane lipids of the hepatocyte which could result to increased generation of reactive oxygen species (ROS).
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